The Motocross World Championship, known as MXGP since 2014, started in 1957 and is one of the hardest and most physical motorsports. KTM's history in MXGP began in the 1970s, with Red Bull KTM Factory Racing being a top team. They have won 15 MX2 titles with the KTM 250 SX-F and 8 MXGP championships with the KTM 450 SX-F and KTM 350 SX-F since 2010.

Red Bull KTM's team size has varied, currently featuring four riders. MX2, for riders under 23, is a stepping stone to MXGP. Each class has two 30-minute motos per Grand Prix, plus a Saturday Qualification Heat with points.

For 2024, the lineup remains the same: Jeffrey Herlings on the KTM 450 SX-F, and Andrea Adamo, Liam Everts, and Sacha Coenen on the KTM 250 SX-F in MX2. The MXGP schedule includes 20 rounds in 15 countries, ending in September with the FIM Motocross of Nations.

For 2024 the Red Bull KTM North American wing will enter 2023 450SX Champion Chase Sexton, who will make his debut in the new orange colours, partnered by Aaron Plessinger on the 450SX-F. In the 250 division, former MX2 World Champion, Tom Vialle will enter his second season of AMA racing, alongside new teammate Julien Beaumer.